self-expandable valves corevalve  (CoreValve Inc)

Journal: Circulation. Cardiovascular Interventions

Article Title: Pathology of Self-Expanding Transcatheter Aortic Bioprostheses and Hypoattenuated Leaflet Thickening

doi: 10.1161/CIRCINTERVENTIONS.124.014523

Figure Lengend Snippet: Representative images of pathological findings of transcatheter aortic valves (TAVs). A through C show a case with severe leaflet thrombosis. A , Gross picture of the aortic annulus with a self-expanding TAV, viewed from the aortic side. Probes indicate the ostia of coronary arteries. Non-coronary cusp was filled with acute thrombus. B and C , Histological images of the leaflet stained with Movat pentachrome, showing acute thrombus on the aortic surface of the leaflet, extending from the base to the free edge. The thrombus consists of fibrin, platelets, and inflammatory cells. D through F show a case with severe pannus formation. D , Gross picture of the aortic annulus with a self-expanding TAV, viewed from the aortic side. E and F , Histological images of the leaflet stained with Movat pentachrome, showing a thickened pannus consisting of smooth muscle cells and proteoglycan-collagen. G and H show a case with leaflet tears. G , The red arrow indicates the tear located on the basal side of the leaflet. H and I , Histological images of the leaflet with a tear. The red arrow indicates the perforation site where fibrin deposition and inflammatory cell infiltration were observed. J through L demonstrate a case of severe intrinsic calcification. J , Gross picture of an explanted TAV in the view from the aortic side. Calcific nodules are seen on the surface of all 3 leaflets. K and L , Histological sections of the leaflet stained with Movat pentachrome, revealing calcific nodules composed of calcium fragments (Ca 2+ ) and fibrin, with disruption of the normal leaflet structure.

Article Snippet: From 2011 to 2021, CVPath Institute received 123 self-expanding transcatheter aortic valves (TAVs; CoreValve, Evolut R, and Evolut PRO; Medtronic, MN) obtained at autopsy or surgical explant from a population of >7500 participants across 11 clinical trials ( Table S1 ).

Techniques: Staining, Disruption

Journal: Circulation. Cardiovascular Interventions

Article Title: Pathology of Self-Expanding Transcatheter Aortic Bioprostheses and Hypoattenuated Leaflet Thickening

doi: 10.1161/CIRCINTERVENTIONS.124.014523

Figure Lengend Snippet: Thrombus type by implant duration. A , The prevalence and types of thrombi on the leaflets, categorized by implant duration. B , The median duration of transcatheter heart valve implant, stratified by thrombus type. Max indicates maximum; and Min, minimum.

Article Snippet: From 2011 to 2021, CVPath Institute received 123 self-expanding transcatheter aortic valves (TAVs; CoreValve, Evolut R, and Evolut PRO; Medtronic, MN) obtained at autopsy or surgical explant from a population of >7500 participants across 11 clinical trials ( Table S1 ).

Techniques:

Journal: Circulation. Cardiovascular Interventions

Article Title: Pathology of Self-Expanding Transcatheter Aortic Bioprostheses and Hypoattenuated Leaflet Thickening

doi: 10.1161/CIRCINTERVENTIONS.124.014523

Figure Lengend Snippet: Representative images of intrinsic and extrinsic leaflet calcification, and median transcatheter heart valve duration for each type. A and B , Low- and high-power images of a leaflet with focal intrinsic calcification on the basal side. The black-stained area (red arrows) indicates calcification within the pericardial leaflet. C and D , Low- and high-power images of a leaflet with extrinsic calcification located within acute thrombus on the aortic side. The black-stained area (red arrows) highlights calcification within the thrombus. E , Median duration of implant for each type of calcification. A and C are stained with hematoxylin and eosin (H&E), while B and D are stained with von Kossa. Q indicates quartile.

Article Snippet: From 2011 to 2021, CVPath Institute received 123 self-expanding transcatheter aortic valves (TAVs; CoreValve, Evolut R, and Evolut PRO; Medtronic, MN) obtained at autopsy or surgical explant from a population of >7500 participants across 11 clinical trials ( Table S1 ).

Techniques: Staining

Journal: Circulation. Cardiovascular Interventions

Article Title: Pathology of Self-Expanding Transcatheter Aortic Bioprostheses and Hypoattenuated Leaflet Thickening

doi: 10.1161/CIRCINTERVENTIONS.124.014523

Figure Lengend Snippet: Results of Transcatheter Aortic Valve Frame Analysis: Macro and Radiographic Findings

Article Snippet: From 2011 to 2021, CVPath Institute received 123 self-expanding transcatheter aortic valves (TAVs; CoreValve, Evolut R, and Evolut PRO; Medtronic, MN) obtained at autopsy or surgical explant from a population of >7500 participants across 11 clinical trials ( Table S1 ).

Techniques: